Quinn (Jerry O'Connell), a brilliant grad student, has created a device that opens a wormhole to an infinite number of parallel universes where history has taken different paths. His first test trip goes awry, stranding his physics professor, Arturo (John Rhys-Davies), his friend, Wade (Sabrina Lloyd), and bystander Rembrandt "Crying Man" Brown (Cleavant Derricks) in parallel San Franciscos. Now, this foursome of Sliders must travel from one alternate reality to another in the hope of somehow finding their way home.