Fat cat Garfield (hilariously voiced by Bill Murray) spends his time snoozing, eating lasagne, watching TV and making wisecracks until his owner Jon (Breckin Myer) falls in love with beautiful veterinarian Liz (Jennifer Love Hewitt). She convinces Jon to adopt the adorably dumb puppy Odie, who promptly turns Garfields easy existence upside down. But when an evil dog train abducts Odie, its up to Garfield to get off the couch and lead a heroic rescue mission.