"Rocked by the death of Nelson's fiance, emotions boil over and conflict brews between Cate and Charlotte. Who will go to jail? Will the team get through this? Tensions mount as Deanna lodges a sexual harassment claim against Frank, rocking the ED to its core. The team then goes further into crisis mode when one of their own is found at deaths door and Nelson hits rock bottom forcing Frank into a heartbreaking decision.

Many new faces join the team in 2006, with Mike Vlasek entering as the Head of Surgery and Spence returning - though not to everyones liking. 2006 also brings some light hearted relief when Mike, Cate and Jack get their 15 minutes of fame battling to save a badly injured reality show contestant live on air. Erica and Bart take their lives into their own hands when they try and set Von up with a patient, and Frank makes a surprise trip to Paris in pursuit of love!

The season ends under a black cloud as Cate's partying ways spiral out of control and she is brought into hospital after a drug overdose. At the same time, a disturbed man brings a gun into the ED with disastrous results. Who will survive?"