Season 5's horrific finale left Dean alone as Sam descended into Hell. Now a different man, Dean vows to stop hunting and devote himself to building a family with Lisa and her son Ben. Then, mysteriously, Sam reappears, drawing Dean back into hunting. But all is not as it seems: Sam is different. A soul-shaking discovery proves Dean's suspicions: this is Sam - but not all of him. How the Winchesters confront this greatest challenge yet to their powerful bond is the troubled heart - and soul - of the profound and thrilling 4-Disc, 22-Episode Season Six. As the brothers struggle to reunite, they must also battle deadly supernatural forces: demons, angels, vampires, shape-shifters. And a terrifying new foe called the Mother of All.

Episodes:
Exile on Main St.
Two and a Half Men
The Third Man
Weekend at Bobby's
Live Free or Twihard
You Can't Handle the Truth
Family Matters
All Dogs Go to Heaven
Clap Your Hands If You Believe
Caged Heat
Appointment in Samarra
Like a Virgin
Unforgiven
Mannequin 3: The Reckoning
The French Mistake
And Then There Were None
My Heart Will Go On
Frontierland
Mommy Dearest
The Man Who Would Be King
Let It Bleed
The Man Who Knew Too Much