Raised in African bush country by her zoologist parents, Cady Heron thinks she knows about the survival of the fittest. But the law of the jungle takes on a whole new meaning when the home-schooled 15-year-old enters public high school for the first time.
Trying to find her place among jocks, mathletes and other subcultures, Cade crosses paths with the meanest species of all the Queen Bee, aka the cool and calculating Regina (Rachel McAdams), leader of the schools most fashionable clique, The Plastics. When Cady falls for Reginas ex-boyfriend, though, the Queen Bee is stung and she schemes to ruin Cadys social future. Cadys own claws soon come out as she leaps into a hilarious Girl World war that has the whole school running for cover.