In the 23rd Century Earth's natural resources have been exhausted by mankind and battle rages between the soldiers of the world's four leading corporations: Capitol Bauhaus Mishima and Imperial. When an errant shell destroys a hidden seal a new enemy Necromutants appear by the millions destroying all before them. The Corporations must ban together against the mutants if they are to have any chance of survival. The Corporations' chosen leader Constantine (John Malkovich) plans to abandon the planet and mankind leaving countless innocents to a hopeless violent fate when he is approached with news from Brother Samuel (Ron Perlman) leader of the Brotherhood an ancient monastic order. Desperate to convince Constantine to help change the course of the future he implores the leader to provide him with a ship and crew to pursue the prophecy of the Chronicles.